Core Publications

Rüppel, J. (i.E.). Die Biomarkerisierung der Depression. Eine Soziologie psychiatrischer Wissensproduktion. Frankfurt: Campus.

Rüppel, J. (2019). “Now is a Time for Optimism”. The Politics of Personalized Medicine in Mental Health Research. Science, Technology, & Human Values, 44 (4), 581-611.

Lemke, T., & Rüppel, J. (2019). Social dimensions of preimplantation genetic diagnosis: a literature review. New Genetics and Society, 38 (1), 80–112.

Lemke, T., & Rüppel, J. (2017). Reproduktion und Selektion. Gesellschaftliche Implikationen der Präimplantationsdiagnostik. Wiesbaden: Springer VS.

Heseler, D., Iltzsche, R., Rojon, O., Rüppel, J., & Uhlig, T.D. (eds.) (2017). Perspektiven kritischer Psychologie und qualitativer Forschung. Zur Unberechenbarkeit des Subjekts. Wiesbaden: Springer.

 Manz, U. & Rüppel, J. (2015). Genetisches Wissen und sozialer Ausschluss: Das Beispiel Blutspende. In Lemke, T., & Liebsch, K. (eds.), Die Regierung der Gene: Diskriminierung und Verantwortung im Kontext genetischen Wissens. Wiesbaden: Springer VS.

Most Recent

Rüppel, J. (2021). “Allowing the Data to ‘Speak for Themselves‘”. Die Klassifikation psychischer Störungen und das Imaginäre der computationalen Psychiatrie. Psychiatrische Praxis 48(S 01), S16-S20.

Rüppel, J., & Voigt, T. H. (eds.) (2019). The Death of the Clinic? Emerging biotechnologies and the Reconfiguration of Mental Health. Special Issue of Science, Technology, & Human Values, 44 (4).

Personalized Depression? Investigating the Preconditions, Dynamics and Implications of Psychiatric Biomarker Research (January 2017 to December 2019, German Research Foundation)

Psychiatric research and clinical practice are currently undergoing a transformation many observers regard as a real paradigm shift. While psychiatric interventions have so far been based on the experiences, narratives and behavior of patients, they are increasingly relying on biological parameters, so-called biomarkers. According to the vision of a “personalized psychiatry”, biomarkers provide for a better diagnosis, prognosis and therapy of psychiatric diseases as they indicate disease severity or susceptibility to treatment, thereby making it possible to “tailor” interventions to the specific bodily features and biological characteristics of individuals. Today, a few biomarker-tests are already available while others will enter clinical practice in the foreseeable future.

The proposed research project is the first to sociologically investigate this essential transformation. It starts from the thesis that the new focus on biomarkers not only changes professional practices and the disciplinary boundaries of psychiatry, but will also modify institutional structures and practices and result in new concepts of mental illness and health, psychic and corporal processes. Informed by the research design of situational analysis, the project examines the conditions, dynamics and implications of psychiatric biomarker research using the example of depression. For this purpose, document and media analysis, expert interviews and ethnographies of psychiatric conferences will provide insights into both the practical contexts and the technical preconditions of biomarker research and the expectations, hopes and fears within the psychiatric arena that go along with the introduction and proliferation of biomarkers for depression. The project contributes to the sociology of psychiatric knowledge by combining an analytics of government following the work of Michel Foucault with insights from Science and Technology Studies. It investigates the historical ontology of depression as a fluid and contested medical classification and seeks to conceptually sharpen the notion of biomarkerization. Beyond the scientific objectives, the research project also provides empirical insights and theoretical reflections highly relevant for the public debate on the societal implications of the vision of a personalized psychiatry.

The biomarkerization of depression. Reconfigurations of health and illness in contemporary psychiatric knowledge production (since 01/2016, German National Academic Foundation)

Psychiatric diagnosis and interventions are based on behavioral and experiential symptoms, codified especially in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases and Related Health Problems (ICD). Mental health researchers, however, are intensively seeking to identify biological parameters – so-called biomarkers – that are supposed to supplement or replace these ‘descriptive’ diagnostic criteria. The PhD project empirically investigates this search for biomarkers with a special focus on mood disorders. Based on ethnographic fieldwork, qualitative interviews, and document analysis, I map related expectations, hopes and fears (e.g. the vision of ‘personalized psychiatry’) and delineate epistemic strategies enacted by various actors in the fields of genomics, proteomics and brain imaging. I assume that the search for biomarkers might significantly reconfigure mental disorders and may already be transforming the knowledge infrastructure of the psy-disciplines – even though this endeavour has largely failed so far.